Research Progress in Immune Checkpoint Inhibitors Combination Therapy Applied to Non-small Cell Lung Cancer after EGFR Mutation-targeted Therapy Resistance / 中国肺癌杂志

With the development of precision medicine for lung cancer, targeted therapy has greatly improved the survival and prognosis of patients with advanced non-small cell lung cancer (NSCLC), but the occurrence of acquired drug resistance ultimately leads to patients with no targeted drugs available and no standard treatment options for this group of patients afterwards. The emergence of immune checkpoint inhibitors (ICIs) has revolutionized the treatment of advanced NSCLC. However, due to the unique features of NSCLC with epidermal growth factor receptor (EGFR) mutation, such as immunosuppressive tumor microenvironment (TME), single ICIs treatment has limited clinical benefits in NSCLC patients with EGFR mutation, and the combination of ICIs with chemotherapy and/or targeted therapies is the trend. This review further discusses potential subpopulations with EGFR mutations that may benefit from ICIs treatment, and analyzes how decisions can be made in the era of combined immunotherapy to maximize the efficacy of ICIs treatment in EGFR mutation targeted therapy for NSCLC patients with drug resistance, with the aim of achieving individualized treatment.

THE ANALYSIS OF THE CONSTITUTION OF DIETS AND NUTRITIONAL STATUS OF INHABITANTS IN DANDONG / 营养学报

This paper collected and analysed the materials concernig constitution and the nutritional level of the diets of inhabitants in Dandong city from 1959 to 1985. The results showed 1) Nutrients level of the diets increased with years and became rational. Intakes of energy and protein were over 110% and 97.1% of the RDA:the protein provided 10.5%, fat 30% and carbohydrate 58% of total energy intake; and 13.2% of protein originated from animal sources. 2) The weight of new-borns and children was less than that in developed countries. 3) The weight of children at age 8 and 14 increased 0.11 (boy), 0.06 (girl) and 0.33, 0.2lkg respectively. The height of the boys increased 0.37, 0.51 cm and the girls 0.28, 0.30 cm respectively. The increased rate is quicker. 4) At the age 0-7, the incidence of the des-eases caused by malnutrition declined yearly but incidence of rickets dropped down less. This may concern less sunning and less VD of the diets.